Use of high-dose fluconazole as salvage therapy for cryptococcal meningitis in patients with AIDS.
نویسندگان
چکیده
Eight patients with AIDS were treated orally with 800 mg of fluconazole daily for cryptococcal meningitis for a mean duration of 4.5 months. Previous antifungal treatment had failed for all of the patients. No major toxicity was observed. Three patients died from cryptococcal infection. High-dose fluconazole may be effective salvage therapy for cryptococcal meningitis.
منابع مشابه
Outcome of AIDS-associated cryptococcal meningitis initially treated with 200 mg/day or 400 mg/day of fluconazole
BACKGROUND AIDS-associated cryptococcal meningitis has a high mortality. Fluconazole was the only systemic antifungal therapy available in our centre. From 1999-2001 we used low-dose fluconazole (200 mg daily initially), and did not offer therapy to patients perceived to have poor prognoses. In 2001 donated fluconazole became available, allowing us to use standard doses (400 mg daily initially)...
متن کاملFluconazole penetration into the prostatic fluid of patients with AIDS-associated cryptococcal meningitis.
Sir, Cryptococcus neoformans causes progressive meningoencephalitis in up to 10% of patients with AIDS. The prostate gland is thought to be a common site for persistent C. neoformans infection following amphotericin B therapy for cryptococcal meningitis in patients with AIDS. Furthermore, positive cultures of post-prostatic massage urine have been found in 29% of patients in whom cryptococcal m...
متن کاملRecent advances in the management of cryptococcal meningitis in patients with AIDS.
The optimum regimen for the treatment of cryptococcal meningitis in patients with AIDS is still not totally clear. The triazoles fluconazole and itraconazole are associated with response rates of 50%-60%. Amphotericin B appears to be associated with a more rapid clearance of organisms, and there are some data suggesting that initial therapy with amphotericin B is preferable to that with triazol...
متن کاملEditorial response: A comparison of itraconazole versus fluconazole as maintenance therapy for AIDS-associated cryptococcal meningitis.
Fluconazole at a dosage of 200 mg daily has again been is effective, while those with persistent urinary cryptococcosis should receive at least 400 mg daily of fluconazole. demonstrated to be highly effective in reducing the risk of relapse after recovery from cryptococcal meningitis [1]. UnforAn interesting note in the clinical study reported by Dr. Saag and colleagues was the possible adjuvan...
متن کاملRetrospective Study of Cryptococcal Meningitis With Elevated Minimum Inhibitory Concentration to Fluconazole in Immunocompromised Patients
Background. Mortality for cryptococcal meningitis remains significant, in spite of available treatment. Resistance to first-line maintenance therapy, particularly fluconazole, has been reported. Methods. A retrospective chart review was performed on immunocompromised patients with cryptococcal meningitis, who had susceptibility testing performed between January 2001 and December 2011, at 3 ho...
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 36 3 شماره
صفحات -
تاریخ انتشار 1992